TCO-carbonylamino-benzamido-PEG3 NHS ester
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group for ultrafast IEDDA ligation and an NHS ester for efficient amine coupling. The PEG3 spacer enhances solubility and compact flexibility, making it especially ideal for dual-functional bioconjugation, probe development, and targeted drug delivery.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free ligation with tetrazines.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG3 Spacer: Provides solubility and steric accessibility.
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Dual Reactivity: Supports orthogonal conjugation strategies.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Links thiol-free amines with tetrazine-functional biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds for orthogonal therapeutic design.
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Synthetic Chemistry: Useful for modular linker synthesis.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product combines ultrafast tetrazine reactivity with amine-targeted conjugation in a PEG3 scaffold, specifically offering solubility and compact flexibility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
