TCO-PEG3-amine
This product is a heterobifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG3 spacer, and a terminal amine. It specifically enables rapid tetrazine click chemistry and amide coupling, offering compact length, solubility, and orthogonal reactivity.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via IEDDA click chemistry.
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Primary Amine: Couples with carboxyls, NHS esters, or activated linkers.
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PEG3 Spacer: Provides solubility and compact spacing.
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Dual Reactivity: Combines click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links tetrazine-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with click and amine handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates rapid tetrazine click chemistry with amine reactivity in a PEG3 scaffold, specifically offering compact and versatile conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
