TCO-PEG6-acid
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group, a PEG6 spacer, and a terminal carboxylic acid. The TCO enables ultrafast copper-free click chemistry with tetrazines, while the carboxyl group allows coupling to amines through amide bond formation. The PEG6 chain improves solubility, flexibility, and accessibility, making this reagent especially ideal for bioconjugation and drug delivery.
Key Features and Benefits
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TCO Group: Supports rapid copper-free ligation with tetrazines via inverse electron-demand Diels–Alder (IEDDA) chemistry.
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Carboxylic Acid Group: Enables amide bond formation with amines for versatile coupling.
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PEG6 Spacer: Provides solubility, flexibility, and reduces steric hindrance in conjugation.
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Bioorthogonal Reactivity: Allows selective ligation under physiological conditions without metal catalysts.
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High Purity: Manufactured to ≥95% purity for reproducible performance.
Applications
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Bioconjugation: Couples biomolecules via TCO–tetrazine ligation or amide chemistry.
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Drug Delivery: Serves as a linker for PEGylated therapeutics and targeted carriers.
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Probe Development: Builds imaging and diagnostic probes with TCO functionality.
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Chemical Biology: Enables orthogonal labeling strategies in complex biological systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, protected from moisture and light.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates rapid TCO click chemistry with a reactive carboxyl group and a solubilizing PEG6 spacer, making it an especially excellent tool for probe development, drug delivery, and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
