Methyltetrazine-NHS Ester
This product is a heterobifunctional reagent featuring a methyltetrazine group and an N-hydroxysuccinimide (NHS) ester. The methyltetrazine reacts ultrafast with trans-cyclooctene (TCO) in copper-free IEDDA ligation, while the NHS ester couples efficiently with primary amines to form stable amide bonds. This combination provides orthogonal reactivity, making it especially useful for protein labeling, probe development, and drug delivery.
Key Features and Benefits
-
Methyltetrazine Group: Enables rapid, copper-free click chemistry with TCO.
-
NHS Ester: Couples efficiently with amines for stable amide formation.
-
Orthogonal Reactivity: Supports dual, bioorthogonal conjugation strategies.
-
Compact Design: Minimizes steric hindrance in labeling applications.
-
High Purity: Produced to ≥95% purity for reliable results.
Applications
-
Protein and Antibody Labeling: Provides dual handles for selective modifications.
-
Bioconjugation: Links TCO- and amine-containing biomolecules.
-
Probe Development: Builds tetrazine-based imaging and diagnostic probes.
-
Drug Delivery: Functions as a modular linker in targeted therapeutics.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light-protected container.
-
Handling: Use freshly prepared solutions; NHS esters are moisture-sensitive.
This product integrates ultrafast tetrazine reactivity with amine-coupling functionality, specifically offering a versatile tool for multifunctional conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
