Tetrazine-NHS ester
This product is a heterobifunctional linker containing a tetrazine moiety and an NHS ester. It specifically enables rapid IEDDA bioorthogonal click chemistry and efficient amine coupling, offering compact design, solubility, and dual reactivity.
Key Features and Benefits
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Tetrazine Group: Reacts rapidly with strained alkenes or alkynes via IEDDA click chemistry.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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Compact Scaffold: Provides minimal steric hindrance and efficient reactivity.
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Dual Reactivity: Combines tetrazine bioorthogonal chemistry with amine coupling.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links tetrazine-modified and amine-reactive biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with orthogonal handles for targeted therapeutics.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates fast tetrazine click chemistry with NHS-activated amine conjugation, specifically providing a compact and versatile tool for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
