Val-Cit-PAB-OH Linker: An Overview
Val-Cit-PAB-OH (CAS# 159857-79-1) is a key chemical linker used in drug delivery and biochemical applications. It consists of:
- Val-Cit (Valine-Citrulline): This peptide sequence undergoes enzymatic cleavage, triggering the controlled release of attached drugs.
- PAB (p-Aminobenzyl): Acts as a spacer, holding the drug securely until the linker cleaves.
Key Benefits:
- Controlled Release: Delivers therapeutic agents precisely at targeted sites through enzyme-triggered cleavage.
- Stable Attachment: Keeps drugs securely attached until release, enhancing drug stability.
Main Uses:
- Drug Delivery: Creates prodrugs that release active pharmaceuticals at specific locations in the body.
- Bioconjugation: Links drugs or biomolecules to delivery systems, improving targeting and reducing side effects.
Val-Cit-PAB-OH drives innovation in drug delivery systems and controlled-release therapies, helping pharmaceutical research develop more precise treatments.
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