Val-Ala-PAB-OH
This product is a dipeptide linker consisting of valine, alanine, and a para-aminobenzyl (PAB) spacer with a terminal hydroxyl group. This structure is commonly used in protease-sensitive drug linkers, specifically where the Val–Ala sequence provides enzymatic cleavage and the PAB moiety acts as a self-immolative spacer for controlled payload release.
Key Features and Benefits:
-
Protease-Sensitive Dipeptide: Val–Ala sequence recognized and cleaved by specific proteases.
-
PAB Spacer: Self-immolative group ensures efficient release of active payloads.
-
Hydroxyl Terminus: Provides a functional handle for further derivatization or conjugation.
-
High Purity: Ensures reproducibility in drug linker design and bioconjugation.
-
Proven Utility: Widely used in antibody–drug conjugates (ADCs) and targeted delivery systems.
Applications:
-
ADC Linker Design: Enables protease-triggered release of cytotoxic agents.
-
Drug Delivery: Supports targeted release strategies in prodrugs and conjugates.
-
Bioconjugation: Facilitates controlled linker–payload attachment with enzymatic cleavability.
-
Synthetic Chemistry: Useful intermediate for developing cleavable linkers in advanced scaffolds.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) and avoid prolonged exposure to heat or moisture.
This product combines a cleavable dipeptide with a self-immolative PAB spacer, making it a key component in drug linker systems specifically for ADCs and controlled release applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
