Tritylthiol-Poly(L-Glutamic Acid), MW 2.5K (Trt-SH-pGlu, MW 2,500)
- Structure: Negatively charged synthetic polyamino acid with γ‑peptide‑linked L‑glutamic acid units, one terminal trityl‑protected thiol (Trt‑SH) group, and one carboxyl (COOH) per repeat unit.
- Key Properties: White/off‑white crystalline solid; soluble in water (alkaline), dichloroacetic acid, chloroform, warm DMF, and dioxane.
- Core Function: Trityl group protects thiol; easily cleaved by TFA to expose reactive free thiol (‑SH) for selective bioconjugation.
- Applications: Drug conjugation, protein labeling, layer‑by‑layer surface coating, stimuli‑responsive delivery systems.
- Storage: −20 °C, protected from light and moisture.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.