Tritylthiol-Poly(L-Glutamic Acid), MW 20K is a thiol-functionalized poly(amino acid) with a trityl-protected thiol group. It combines a carboxyl-rich poly(L-glutamic acid) chain with protected thiol functionality specifically for controlled conjugation and biomaterial research.
Key Features and Benefits
- Poly(amino acid) Backbone: Poly(L-glutamic acid) specifically provides a biodegradable polymer backbone with abundant pendant carboxyl groups.
- MW 20K: Provides a higher molecular weight poly(L-glutamic acid) chain with multiple glutamic acid residues and abundant carboxyl functionality.
- Trityl-Protected Thiol: The terminal thiol carries a trityl protecting group that specifically helps limit premature oxidation and unwanted thiol reactions.
- Protected Reactive Terminus: Trityl protection keeps the thiol masked during handling and selected functionalization steps.
- Thiol Activation: Removal of the trityl protecting group exposes a free thiol for subsequent conjugation.
- Thiol-Reactive Chemistry: After deprotection, the thiol can react with compatible maleimide, OPSS, and other thiol-reactive functionalities.
- Carboxyl-Rich Structure: Pendant carboxyl groups specifically provide additional sites for polymer modification and conjugation strategies.
- Multifunctional Platform: Combines protected thiol chemistry with the carboxyl-rich properties of poly(L-glutamic acid).
Applications
- Controlled Thiol Conjugation: Trityl protection allows activation of the terminal thiol before coupling with compatible reactive molecules.
- Bioconjugation: The deprotected thiol supports coupling with compatible maleimide, OPSS, and other thiol-reactive compounds.
- Polymer Functionalization: Provides both terminal thiol and pendant carboxyl functionality for preparing modified polymer conjugates.
- Nanoparticle Functionalization: Supports thiol-mediated modification of compatible nanoparticle and polymeric systems.
- Surface Modification: The deprotected thiol provides a reactive handle for functionalizing compatible surfaces.
- Gold Surface Functionalization: Free thiol functionality can interact with compatible gold surfaces and nanoparticles.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. After deprotection, minimize prolonged air exposure to reduce free-thiol oxidation.
Tritylthiol-Poly(L-Glutamic Acid), MW 20K combines a carboxyl-rich poly(amino acid) chain with a protected terminal thiol and specifically supports controlled thiol conjugation, polymer functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.