Thiol-PEG4-t-butyl ester
This product is a high-purity heterobifunctional PEG linker featuring a terminal thiol group and an acid-labile tert-butyl ester, connected by a PEG4 spacer. The thiol group enables site-specific conjugation to maleimides or other thiol-reactive moieties, while the tert-butyl ester can be selectively cleaved under mild acidic conditions to yield a carboxylic acid. The PEG4 chain provides hydrophilicity and flexibility, making it especially useful for bioconjugation, surface modification, and drug delivery applications.
Key Features
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Terminal thiol and t-butyl ester groups for orthogonal reactivity
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Selective t-butyl ester deprotection to generate carboxylic acid
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PEG4 spacer for hydrophilicity and reduced steric hindrance
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High chemical purity for reproducible performance
Applications
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Protein, peptide, and antibody conjugation
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Prodrug and polymer–drug conjugate synthesis
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Nanoparticle surface modification
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Hydrophilic spacer in material science
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Allow to reach room temperature before opening
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Avoid repeated freeze–thaw cycles
This product combines a reactive thiol with an acid-labile t-butyl ester, linked by a PEG4 chain specifically for hydrophilicity, flexibility, and orthogonal conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
