Thalidomide-O-PEG4-NHS ester
This product is a heterobifunctional linker combining thalidomide for cereblon (CRBN) recruitment with a PEG4 spacer and an NHS ester for rapid amine coupling. This design specifically provides solubility, steric flexibility, and targeted functionality, making it ideal for PROTAC development, drug delivery, and bioconjugation.
Key Features and Benefits:
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Thalidomide Moiety: Binds CRBN, enabling PROTAC and targeted degradation strategies.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG4 Spacer: Enhances solubility and provides steric accessibility.
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Dual Reactivity: Supports targeted conjugation in complex synthetic workflows.
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High Purity: Ensures reproducibility for research and drug discovery.
Applications:
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PROTAC Development: Builds cereblon-recruiting linkers for targeted protein degradation.
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Drug Delivery: Enhances solubility and linker flexibility in therapeutic scaffolds.
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Probe Development: Creates functionalized probes for mechanistic studies.
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Bioconjugation: Provides controlled amine reactivity in stepwise synthesis.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product combines CRBN-targeting thalidomide with amine-reactive chemistry, specifically offering a versatile scaffold for PROTAC synthesis and advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
