Thalidomide-O-PEG4-Amine
This product is a heterobifunctional linker with a thalidomide moiety for cereblon (CRBN) recruitment and a terminal amine for versatile coupling. The PEG4 spacer specifically enhances solubility, flexibility, and spacing, making it widely used in PROTAC development, drug delivery, and targeted bioconjugation.
Key Features and Benefits:
-
Thalidomide Moiety: Recruits CRBN E3 ligase for targeted protein degradation.
-
Amine Group: Couples with carboxyls, NHS esters, and other electrophiles.
-
PEG4 Spacer: Improves solubility, flexibility, and steric accessibility.
-
Dual Functionality: Combines E3 ligase binding with versatile conjugation chemistry.
-
High Purity: Ensures reproducibility in drug discovery and research workflows.
Applications:
-
PROTAC Development: Core linker for CRBN-based protein degraders.
-
Drug Delivery: PEGylated design enhances solubility and pharmacokinetics.
-
Bioconjugation: Couples ligase-recruiting thalidomide with therapeutic payloads.
-
Probe Development: Builds targeted chemical biology tools for research.
Storage and Handling:
-
Storage: Store at –20 °C, protected from moisture and light.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain amine reactivity.
This product combines CRBN recruitment with amine conjugation chemistry, making it an especially versatile reagent for PROTAC design, targeted delivery, and advanced bioconjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
