Tetrazine-PEG6-Amino-Boc is a versatile reagent featuring a tetrazine group for rapid bioorthogonal IEDDA reactions with strained alkenes (e.g., TCO) and a Boc-protected amino group for controlled functionalization. The PEG6 spacer ensures enhanced solubility, flexibility, and reduced steric hindrance, making it ideal for bioconjugation, imaging, and therapeutic development.
Features
- Tetrazine Group: Enables fast, selective bioorthogonal conjugation.
- Boc-Protected Amine: Provides controlled deprotection for versatile functionalization.
- PEG6 Spacer: Enhances solubility and reduces steric interference.
- High Purity: ≥95% for reproducible results.
- Biocompatibility: Ideal for use in biological systems.
Applications
- Bioconjugation: Site-specific modification of biomolecules.
- Imaging: Development of fluorescent and radiolabeled probes.
- Therapeutics: Preparation of drug delivery systems and conjugates.
- Diagnostics: Functionalization for biosensors and assays.
- Chemical Biology: Studies in live-cell and complex biological environments.
References:
1. Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation, Mark R MR Karver et. al, Bioconjugate Chemistry, 22(11), 2263-2270 (2011)
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
