Tetrazine-PEG4-SSPy is a multifunctional reagent featuring a tetrazine group for rapid bioorthogonal IEDDA reactions, a redox-sensitive disulfide bond for controlled cleavability, and a pyridyl disulfide (SSPy) group for thiol-based conjugation. The PEG4 spacer ensures excellent solubility and reduces steric hindrance, making it an ideal tool for diverse applications in bioconjugation, chemical biology, and drug delivery.
Features
- Tetrazine Group: Enables fast and selective bioorthogonal reactions with strained alkenes.
- Pyridyl Disulfide (SSPy) Group: Reacts specifically with thiols for stable disulfide bonds.
- Redox-Sensitive Disulfide Bond: Provides cleavability in reducing environments.
- PEG4 Spacer: Improves solubility and minimizes steric interference.
- High Purity: ≥95% for reliable and consistent performance.
- Biocompatibility: Suitable for complex biological and chemical environments.
Applications
- Bioconjugation: Dual labeling using tetrazine and thiol-specific SSPy chemistry.
- Drug Delivery: Design of redox-cleavable systems for targeted release.
- Imaging: Development of fluorescent or radiolabeled probes.
- Diagnostics: Functionalization for biosensors and assays.
- Chemical Biology: Studies in live cells and complex biological systems.
- Material Science: Functionalization of hydrogels and polymers.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
