TCO Phosphoramidite C6 is a reagent used to introduce trans-cyclooctene (TCO) groups into oligonucleotides during synthesis. The TCO moiety enables rapid and selective bioorthogonal conjugation with tetrazine-containing molecules via inverse electron-demand Diels-Alder (IEDDA) reactions.
Key Features:
- Adds TCO groups to oligonucleotides during solid-phase synthesis.
- Enables fast and specific conjugation with tetrazine-modified probes.
- Highly compatible with imaging, diagnostics, and therapeutic applications.
Applications:
- Oligonucleotide Labeling: Facilitates TCO incorporation for efficient conjugation.
- Bioorthogonal Chemistry: Allows precise modifications in biological systems.
- Imaging and Diagnostics: Creates labeled oligonucleotides for tracking nucleic acids.
- Therapeutic Development: Supports conjugation with functional molecules for targeted therapies.
TCO Phosphoramidite simplifies oligonucleotide functionalization for advanced molecular biology applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
