TCO-PEG8-acid
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a terminal carboxylic acid for amide coupling. The PEG8 spacer enhances solubility, flexibility, and spacing, making it especially useful for probe development, ADCs, and drug delivery.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA click chemistry with tetrazines.
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Carboxylic Acid: Couples efficiently with primary amines under mild conditions.
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PEG8 Spacer: Provides solubility, hydrophilicity, and steric separation.
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Orthogonal Reactivity: Supports dual and stepwise conjugation strategies.
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High Purity: Ensures reproducibility in advanced research and therapeutic applications.
Applications:
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ADC Development: Serves as a cleavable linker for targeted therapeutics.
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Probe Development: Builds TCO-modified probes for diagnostics and imaging.
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Bioconjugation: Combines click-ready and amine-reactive handles.
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Drug Delivery: Provides PEGylated scaffolds with enhanced solubility.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light.
This product combines ultrafast tetrazine ligation with carboxyl functionality in a PEG8 scaffold, specifically offering solubility and versatility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
