TCO-PEG36-acid
This product is a long-chain PEG linker functionalized with a trans-cyclooctene (TCO) group and a terminal carboxylic acid. The extended PEG36 spacer provides high aqueous solubility, flexibility, and reduced steric hindrance, while the TCO enables ultrafast copper-free click reactions with tetrazines.
Key Features and Benefits
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TCO Handle: Supports rapid inverse electron-demand Diels–Alder (IEDDA) click reactions with tetrazines.
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PEG36 Spacer: Increases solubility, biocompatibility, and spacing between conjugated molecules.
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Carboxylic Acid Group: Allows amide bond formation with amines for versatile conjugation.
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Bioorthogonal Reactivity: Enables selective ligation under physiological conditions without metal catalysts.
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High Purity: Manufactured to ≥95% purity for consistent and reproducible results.
Applications
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Bioconjugation: Couples biomolecules, drugs, or probes via TCO–tetrazine ligation.
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Drug Delivery: Serves as a linker for PEGylated therapeutics and targeted nanocarriers.
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Probe Development: Builds TCO-functionalized imaging and diagnostic probes.
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Chemical Biology: Facilitates bioorthogonal labeling in living systems.
Storage and Handling
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Storage: Keep at –20 °C in a sealed container, protected from moisture and light.
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Handling: Use under inert atmosphere when possible; avoid prolonged exposure to heat.
This product integrates ultrafast TCO click chemistry with a highly soluble PEG36 spacer and a reactive carboxyl group, making it an especially ideal linker for advanced bioconjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
