TCO-PEG3-DBCO
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group, a PEG3 spacer, and a dibenzocyclooctyne (DBCO) moiety. The TCO enables ultrafast copper-free click chemistry with tetrazines, while the DBCO reacts rapidly with azides via SPAAC. The PEG3 spacer specifically improves solubility and reduces steric hindrance, making this a compact yet versatile reagent for dual-labeling strategies.
Key Features and Benefits
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TCO Group: Supports rapid copper-free ligation with tetrazines (IEDDA chemistry).
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DBCO Group: Reacts efficiently with azides via SPAAC click chemistry.
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PEG3 Spacer: Enhances solubility and flexibility for efficient conjugation.
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Dual Reactivity: Combines orthogonal click reactions in one linker.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Couples tetrazine- and azide-modified biomolecules in a single construct.
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Probe Development: Builds dual-functional probes for imaging and diagnostics.
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Drug Delivery: Enables orthogonal labeling in ADC and carrier design.
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Chemical Biology: Supports advanced dual-click strategies in living systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines two powerful copper-free click handles on a PEG3 backbone, providing an especially versatile tool for dual-labeling, probe development, and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
