TCO-PEG3-Biotin
This product is a multifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG3 spacer, and a biotin moiety. It enables rapid bioorthogonal click chemistry with tetrazines while providing high-affinity biotin–streptavidin binding, making it ideal for dual labeling and detection.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) chemistry.
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Biotin Moiety: Provides strong affinity binding to streptavidin and avidin systems.
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PEG3 Spacer: Enhances solubility and minimizes steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with affinity-based capture.
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High Purity: Ensures reliable and reproducible results.
Applications
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Bioconjugation: Links tetrazine-modified molecules with biotin-binding systems.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with dual click and affinity handles.
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Material Science: Functionalizes surfaces and nanostructures with bioorthogonal and affinity chemistries.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO click reactivity with biotin–streptavidin affinity in a PEG3 scaffold, specifically providing a compact and versatile linker for bioconjugation and detection applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
