TCO-PEG3-alcohol CAS:2566420-12-8 is a versatile and highly functionalized bioorthogonal reagent utilized in pharmaceutical research and development. It consists of a trans-cyclooctene (TCO) moiety conjugated to a polyethylene glycol (PEG3) linker and an alcohol terminus, providing enhanced water solubility and reduced immunogenicity. This reagent is employed in various applications, including site-specific drug conjugation, controlled release systems, and bioconjugation with tetrazine-labeled biomolecules. TCO-PEG3-alcohol’s exceptional in vivo stability and rapid click chemistry reactivity make it invaluable for designing targeted therapeutics, enabling precise control over pharmacokinetics and biodistribution profiles.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.