TCO-PEG3-acid
This product is a PEG3 linker with a TCO group for rapid tetrazine ligation and a terminal carboxylic acid for amide coupling. The PEG3 spacer specifically improves solubility, flexibility, and spacing, making it effective for bioorthogonal labeling and bioconjugation.
Key Features and Benefits:
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TCO Group: Enables ultrafast inverse electron-demand Diels–Alder (IEDDA) reactions with tetrazines.
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Carboxylic Acid Group: Couples efficiently with primary amines via amide bond formation.
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PEG3 Spacer: Provides hydrophilicity and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Dual Functionality: Combines bioorthogonal click reactivity with versatile conjugation chemistry.
Applications:
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Bioorthogonal Labeling: Supports rapid TCO–tetrazine ligation in vitro and in vivo.
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Bioconjugation: Couples with amines while enabling click chemistry with tetrazines.
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Drug Delivery: PEGylated scaffold improves solubility and circulation.
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Probe Development: Builds targeted imaging or diagnostic tools.
Storage and Handling:
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Storage: Store at –20 °C, sealed and protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain carboxyl and TCO reactivity.
This product combines rapid click chemistry with amine coupling capability in a compact PEG design, making it an especially versatile tool for targeted conjugation and bioorthogonal chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
