TCO-PEG24-NHS ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and an NHS ester for efficient amine coupling. The long PEG24 spacer specifically improves solubility, hydrophilicity, and steric spacing, making it ideal for bioorthogonal labeling, ADC design, and bioconjugation.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA reactions with tetrazines.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG24 Spacer: Provides extended solubility, flexibility, and reduced steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioorthogonal Labeling: Supports ultrafast conjugation in vitro and in vivo.
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ADC Development: Provides cleavable spacing for antibody–drug conjugates.
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Probe Development: Builds tetrazine-reactive probes for imaging and diagnostics.
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Drug Delivery: Enhances pharmacokinetics via PEGylated, bioorthogonal design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect TCO from prolonged light exposure.
This product combines long PEG spacing with dual reactive handles, making it an especially versatile reagent for bioorthogonal labeling, ADC design, and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
