TCO-PEG2-amine
This product is a heterobifunctional PEG linker with a trans-cyclooctene (TCO) group, a PEG2 spacer, and a terminal primary amine. The TCO reacts ultrafast with tetrazines via copper-free IEDDA ligation, while the amine couples efficiently with carboxyls or NHS esters to form stable amides. The PEG2 spacer improves solubility and reduces steric hindrance, making this reagent especially compact yet versatile for bioconjugation.
Key Features and Benefits
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TCO Group: Performs ultrafast, copper-free IEDDA ligation with tetrazines.
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Amine Group: Couples with carboxyls or NHS esters for stable amides.
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PEG2 Spacer: Enhances solubility and flexibility in a compact linker.
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Dual Reactivity: Supports orthogonal click chemistry and amine coupling.
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High Purity: Produced to ≥95% purity for reliable use.
Applications
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Bioconjugation: Links TCO- and amine-modified biomolecules.
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Protein and Antibody Labeling: Provides dual orthogonal handles.
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Probe Development: Builds compact tetrazine-reactive probes.
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Drug Delivery: Functions as a short PEG linker in therapeutic conjugates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product integrates ultrafast tetrazine ligation with amine reactivity in a compact PEG2 scaffold, specifically offering a reliable tool for multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
