TCO-PEG1-Val-Cit-PAB-PNP
This product is a cleavable linker designed for antibody-drug conjugates (ADCs) and targeted delivery. It features a TCO (trans-cyclooctene) handle for click chemistry, a short PEG1 spacer, the protease-cleavable Val-Cit dipeptide, and a self-immolative PAB group terminating in a reactive PNP carbonate specifically for efficient payload attachment.
Key Features and Benefits:
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TCO Handle: Enables rapid bioorthogonal click chemistry.
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PEG1 Spacer: Improves solubility and reduces steric hindrance.
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Val-Cit Dipeptide: Cleaved by cathepsin B for intracellular drug release.
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PAB-PNP Group: Self-immolative spacer with active carbonate for efficient conjugation.
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High Purity: Ensures reproducibility for ADC development.
Applications:
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Antibody-Drug Conjugates (ADCs): Controlled drug release in targeted cells.
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Bioconjugation: Site-specific linkage of therapeutic payloads.
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Drug Delivery Systems: Spacer-linker for precise pharmacokinetics.
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Research Tools: Model compound for linker-payload studies.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) for optimal stability.
This product combines click chemistry functionality with protease-cleavable and self-immolative release design, making it an especially versatile linker for advanced ADC research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
