TCO-PEG1-acid
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a terminal carboxylic acid for amide coupling. The short PEG1 spacer provides compact solubility and minimal steric hindrance, making it especially ideal for bioorthogonal labeling, probe design, and multifunctional conjugation.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA ligation with tetrazines.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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PEG1 Spacer: Provides compact design with solubility and accessibility.
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Dual Reactivity: Combines bioorthogonal and classical amide chemistry.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioorthogonal Labeling: Fast tetrazine ligation in vitro and in vivo.
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Probe Development: Builds TCO-modified probes for imaging and diagnostics.
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Drug Delivery: Provides compact PEGylated scaffolds for conjugates.
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Bioconjugation: Supports orthogonal, dual-functional strategies.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect TCO from prolonged light exposure.
This product integrates ultrafast bioorthogonal ligation with amine-reactive acid chemistry in a compact PEG scaffold, making it an especially versatile tool for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
