TCO-carbonylamino-benzyl NHS ester
TCO-carbonylamino-benzyl NHS ester is a high-purity linker with a TCO for rapid, catalyst-free tetrazine ligation and an NHS ester for efficient amine coupling. The carbonylamino-benzyl spacer enhances reactivity and positioning, making it especially ideal for bioorthogonal labeling, site-specific modification, and fast, high-yield conjugations in both aqueous and organic systems.
Key Features and Benefits
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TCO Group: Enables ultra-fast, catalyst-free inverse-electron-demand Diels–Alder (IEDDA) reaction with tetrazines.
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NHS Ester: Reacts efficiently with primary amines to form stable amide bonds.
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Carbonylamino-benzyl Spacer: Improves reactivity and spatial orientation of functional groups.
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Heterobifunctional Design: Allows orthogonal conjugations for complex biomolecule assembly.
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High Purity: Supplied at >95% purity for reliable and reproducible results.
Applications
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Bioorthogonal labeling of proteins, peptides, and antibodies.
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Site-specific drug conjugation and ADC development.
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Pre-targeted imaging and therapeutic systems.
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Nanoparticle and surface functionalization.
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Fast, selective bioconjugation in live-cell environments.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve NHS ester reactivity.
This product combines rapid TCO–tetrazine click chemistry with efficient amine coupling, optimized by a carbonylamino-benzyl spacer specifically for high reactivity in bioorthogonal labeling and targeted conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.