TCO-carbonylamino-benzamido-PEG2 acid
This product is a linker with a TCO group, benzamido unit, PEG2 spacer, and terminal carboxyl. It specifically supports copper-free click chemistry and amide coupling, offering improved solubility and spacing over the PEG1 analog.
Key Features and Benefits
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TCO Group: Enables rapid copper-free ligation with tetrazines via IEDDA chemistry.
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Carboxylic Acid Group: Couples efficiently with amines for stable amide bonds.
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Benzamido-PEG2 Core: Provides rigidity with moderate spacing for controlled conjugation.
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Dual Reactivity: Combines click chemistry with amide coupling.
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High Purity: Produced to ≥95% purity for consistent bioconjugation results.
Applications
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Bioconjugation: Links TCO-tagged probes or drugs with amine-functionalized biomolecules.
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Probe Development: Builds compact probes for imaging and diagnostics.
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Drug Delivery: Functions as a linker in PEGylated therapeutics with controlled spacing.
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Chemical Biology: Supports orthogonal labeling strategies in complex systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product combines fast TCO click chemistry with amide coupling in a compact PEG2 scaffold, making it an especially versatile tool for probe design, conjugation, and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
