TCO-carbonylamino-benzamido-PEG1 acid
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group, a benzamido unit, a short PEG1 spacer, and a terminal carboxylic acid. The TCO enables ultrafast copper-free click chemistry with tetrazines, while the carboxyl group supports amide bond formation. The benzamido–PEG1 structure offers rigidity with minimal spacing, making it especially suitable for compact conjugation strategies.
Key Features and Benefits
-
TCO Group: Provides rapid, copper-free ligation with tetrazines via IEDDA chemistry.
-
Carboxylic Acid Group: Couples readily with amines for stable amide bonds.
-
Benzamido-PEG1 Core: Offers rigidity and short spacing for compact conjugates.
-
Dual Reactivity: Combines orthogonal click chemistry with amide bond formation.
-
High Purity: Produced to ≥95% purity for reproducible bioconjugation.
Applications
-
Bioconjugation: Couples TCO-tagged probes or drugs with amine-functionalized biomolecules.
-
Probe Development: Builds compact probes for imaging and diagnostics.
-
Drug Delivery: Serves as a linker for PEGylated therapeutics with controlled spacing.
-
Chemical Biology: Facilitates orthogonal labeling strategies in crowded biological environments.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates rapid TCO click reactivity with a carboxyl handle in a compact scaffold, making it especially valuable for probe design, drug delivery, and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
