t-Boc-N-Amido-PEG8-NHS Ester
t-Boc-N-Amido-PEG8-NHS Ester is a high-purity, heterobifunctional PEG linker featuring an NHS ester for rapid amine coupling and a Boc-protected amine for orthogonal conjugation. Moreover, the PEG8 spacer offers excellent aqueous solubility, increased flexibility, and reduced steric hindrance, making it ideal for multistep bioconjugation, drug delivery, and surface modification applications.
Key Features and Benefits:
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Efficient Amine Coupling: NHS ester reacts quickly with primary amines to form stable amide bonds under mild conditions.
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Boc-Protected Amine: Enables selective deprotection for secondary conjugation steps.
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PEG8 Spacer: Improves solubility, reduces nonspecific binding, and enhances biocompatibility.
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Heterobifunctional Design: Allows stepwise or orthogonal labeling for complex molecule assembly.
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High Purity: Supplied at >95% purity for reproducible, consistent results.
Applications:
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Multistep Bioconjugation: Sequentially attach biomolecules or labels in controlled order.
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Antibody and Protein Modification: Introduce PEG chains while retaining a protected amine for further conjugation.
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Surface Functionalization: Modify nanoparticles, hydrogels, or biosensors with controlled chemistry.
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Drug Delivery Systems: Link targeting ligands and therapeutic agents through a stable PEG backbone.
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Diagnostics: Create dual-functional probes for imaging and detection.
Storage and Handling:
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Storage: Store at -20°C, protected from light and moisture.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to prevent NHS hydrolysis.
This product provides reliable orthogonal reactivity with high solubility and flexibility, making it a preferred linker for advanced bioconjugation, PEGylation, and multifunctional probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
