t-Boc-N-Amido-PEG7-NHS ester
This high-purity PEG linker features an NHS ester for amine coupling and a t-Boc–protected amide for acid-labile deprotection. The PEG7 spacer specifically improves solubility, flexibility, and reduces steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
-
NHS Ester – Couples efficiently with primary amines on proteins, peptides, and other biomolecules.
-
t-Boc–Protected Amide – Acid-labile protection supports orthogonal functionalization strategies.
-
PEG7 Spacer – Improves solubility, molecular flexibility, and accessibility of reactive groups.
-
Orthogonal Reactivity – Enables sequential modifications without cross-reactivity.
-
High Purity – Supplied at >95% purity for reproducible performance.
Applications
-
Protein, peptide, and small molecule conjugation
-
Orthogonal linker design for drug delivery and ADCs
-
Multifunctional bioconjugate synthesis
-
Surface and nanoparticle functionalization
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve NHS ester reactivity
This product combines efficient amine coupling via NHS ester with selective t-Boc deprotection, linked by a PEG7 spacer for solubility and flexibility, making it especially ideal for orthogonal bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
