t-Boc-N-Amido-PEG6-amine
This product is a bifunctional PEG6 linker with a Boc-protected amide and a terminal primary amine. The PEG6 spacer provides hydrophilicity and flexibility, while the Boc group offers acid-labile protection for controlled, orthogonal conjugation.
Key Features and Benefits:
-
Boc-Protected Amide: Provides acid-labile protection for stepwise synthesis.
-
Amine Group: Couples efficiently with carboxyls, NHS esters, and other electrophiles.
-
PEG6 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
-
High Purity: Ensures reproducibility in bioconjugation workflows.
-
Orthogonal Reactivity: Supports selective and multistep conjugation strategies.
Applications:
-
Bioconjugation: Attach proteins, peptides, or small molecules with controlled PEG spacing.
-
Drug Delivery: PEGylated linker enhances solubility and pharmacokinetics.
-
Surface Modification: Functionalize nanoparticles, hydrogels, or polymers.
-
Synthetic Chemistry: Useful intermediate in PEGylated scaffolds and advanced materials.
Storage and Handling:
-
Storage: Store at –20 °C, protected from moisture and light.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain Boc and amine stability.
This product combines a PEG6 spacer with Boc protection and an amine handle, making it an especially versatile reagent for orthogonal synthesis and controlled conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
