t-Boc-N-Amido-PEG5-amine
This product is a bifunctional PEG5 linker with a Boc-protected amide and a terminal primary amine. The PEG5 spacer provides solubility and flexibility, while the Boc group offers acid-labile protection for controlled, orthogonal conjugation workflows.
Key Features and Benefits:
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Boc-Protected Amide: Acid-labile protection for selective, stepwise synthesis.
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Amine Group: Couples with carboxyls, NHS esters, and other electrophiles.
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PEG5 Spacer: Provides balanced hydrophilicity and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Reactivity: Enables selective and multistep conjugation strategies.
Applications:
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Bioconjugation: Attach proteins, peptides, or small molecules with controlled PEG spacing.
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Drug Delivery: PEGylated linker enhances solubility, stability, and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, hydrogels, and polymers.
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Synthetic Chemistry: Useful intermediate for PEGylated scaffold construction.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and amine integrity.
This product provides dual reactivity and moderate PEG spacing, making it an especially versatile reagent for orthogonal conjugation, bioconjugation, and advanced material science applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
