t-Boc-N-Amido-PEG16-alcohol
t-Boc-N-Amido-PEG16-alcohol is a high-purity, monofunctional polyethylene glycol (PEG) reagent with a terminal alcohol group and a tert-butyloxycarbonyl (t-Boc)–protected amide functionality. The PEG16 spacer provides excellent hydrophilicity, extended linker length, and reduced steric hindrance. The t-Boc protecting group specifically allows controlled deprotection under mild acidic conditions, offering orthogonal reactivity for multi-step synthesis and advanced bioconjugation strategies.
Key Features and Benefits
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t-Boc–Protected Amide: Enables selective deprotection for orthogonal synthesis.
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PEG16 Spacer: Long, hydrophilic chain enhances solubility and flexibility.
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Terminal Alcohol Group: Allows further functionalization through esterification, ether formation, or oxidation.
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High Purity: Supplied at >95% purity for reproducible results.
Applications
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Multi-step bioconjugation with orthogonal protection strategies.
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Synthesis of functionalized biomolecules, polymers, and nanoparticles.
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Preparation of hydrophilic linkers for drug delivery and diagnostic probes.
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Controlled surface modification and immobilization workflows.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use with anhydrous solvents; avoid prolonged exposure to moisture or strong bases.
A versatile PEG16 linker with a t-Boc–protected amide and terminal alcohol, especially ideal for orthogonal, multi-step conjugation and hydrophilic spacer applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
