t-Boc-N-Amido-PEG15-Azide
t-Boc-N-Amido-PEG15-Azide is a versatile polyethylene glycol (PEG)-based linker with a t-Boc-protected amido group on one end and an azide group on the other. A 15-unit PEG spacer connects these significantly functional groups, enhancing solubility, flexibility, and usability. This compound is especially ideal for applications in bioconjugation, drug delivery, and material science.
Key Features
- Functional Groups:
- A t-Boc-protected amido group supports selective deprotection and chemical modifications.
- An azide group enables efficient click chemistry (CuAAC) reactions.
- PEG Spacer: The 15-unit PEG chain provides excellent solubility and structural flexibility.
- Molecular Weight: Approximately 850–950 g/mol, depending on synthesis.
Applications
1. Bioconjugation
The azide group reacts reliably with alkynes using copper-catalyzed azide-alkyne cycloaddition (CuAAC), forming stable triazole linkages. This makes it an excellent choice for attaching biomolecules like proteins, peptides, or polymers in research and development.
2. Drug Delivery
The 15-unit PEG spacer significantly improves solubility and reduces immunogenicity, making it suitable for creating stable drug delivery systems. The t-Boc-protected amido group enables precise functionalization during multi-step synthesis, ensuring consistent results.
3. Material Science and Surface Modification
This linker works well for functionalizing surfaces and creating bioactive materials. The long PEG spacer provides flexibility and proper spatial arrangement for various surface and nanoparticle modifications.
Handling and Storage
- Store t-Boc-N-Amido-PEG15-Azide at −20°C in a dry, inert environment to keep it stable.
- Protect it from moisture and light to prevent degradation.
- Use it promptly after opening to maintain reactivity and performance.
Overall, this product combines the selectivity of a t-Boc-protected amido group with the reactivity of an azide group, all supported by a 15-unit PEG spacer for solubility and flexibility. Moreover, its unique design makes it a top choice for bioconjugation, drug delivery, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
