t-Boc-N-Amido-PEG12-amine
This product is a high-purity PEG reagent with a terminal Boc-protected amine and a free amine on opposite ends of a PEG12 spacer, specifically offering solubility, flexibility, and selective deprotection for bioconjugation.
Key Features and Benefits
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Boc-Protected Amine – Enables controlled deprotection for stepwise conjugation.
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Free Amine Group – Readily reacts with carboxyls, NHS esters, or other activated groups.
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PEG12 Spacer – Provides excellent solubility, flexibility, and reduced steric hindrance.
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High Purity – Suitable for bioconjugation, linker design, and drug delivery.
Applications
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Dual-functional PEG linker for orthogonal conjugations
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Amide coupling with carboxylic acids and NHS esters
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Stepwise conjugation strategies requiring selective amine protection
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Linker design in antibody–drug conjugates and targeted therapeutics
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.
This product provides a free amine and a Boc-protected amine on a PEG12 spacer, enabling controlled, orthogonal conjugation specifically with improved solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
