t-Boc-N-Amido-PEG12-acid
This product is a bifunctional PEG12 linker with a Boc-protected amide and a terminal carboxylic acid. The PEG12 spacer provides hydrophilicity and flexibility, while the Boc group enables acid-labile protection for controlled, orthogonal conjugation strategies.
Key Features and Benefits:
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Boc-Protected Amide: Stable, acid-labile protection for selective deprotection.
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Carboxylic Acid Group: Couples efficiently with primary amines.
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PEG12 Spacer: Provides solubility, reduced steric hindrance, and extended spacing.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Orthogonal Design: Supports multistep and controlled conjugation.
Applications:
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Bioconjugation: Conjugate proteins, peptides, or biomolecules with controlled spacing.
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Drug Delivery: Enhances solubility and pharmacokinetics through PEGylation.
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Surface Modification: Functionalize nanoparticles, hydrogels, or polymers.
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Material Science: Useful in PEG-based polymers and advanced biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and acid functionality.
This product combines a medium-length PEG spacer with acid-labile Boc protection, making it an especially versatile reagent for orthogonal synthesis and advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
