t-Boc-N-Amido-PEG11-Azide (CAS: 2395004-21-2) combines functionality with versatility. It features a t-Boc-protected amido group on one end and an azide group on the other, making it an essential tool for various chemical and biological applications. The PEG11 spacer, with 11 ethylene glycol units, enhances water solubility, flexibility, and biocompatibility, ensuring excellent performance in demanding environments.
Key Features
Chemical Structure:
- Molecular Formula: C₂₉H₅₇N₃O₁₄
- Molecular Weight: 675 g/mol
- Functional Groups:
- t-Boc-protected amido group
- Azide group
- PEG11 backbone
Physical Properties
- Form: Clear, viscous liquid or low-melting solid
- Solubility: Dissolves easily in water and organic solvents such as DMSO, DMF, methanol, and ethanol.
- Stability: Performs reliably under normal conditions. However, strong acids or high temperatures can break the t-Boc group or decompose the azide.
Applications
1. Bioconjugation and Click Chemistry
The azide group makes this compound a star player in click chemistry. Furthermore, it reacts efficiently with alkynes through copper-catalyzed azide-alkyne cycloaddition (CuAAC), forming stable triazole linkages. This property is particularly useful for modifying biomolecules, nanoparticles, and surfaces.
2. Drug Delivery and Pharmaceuticals
In drug development, the t-Boc-protected amido group allows for precise, selective chemical modifications. Once deprotected, the amido group enhances solubility and facilitates bioavailability, improving the performance of drug delivery systems.
3. Surface Functionalization
The PEG11 spacer offers exceptional flexibility, ensuring adequate spacing for surface modifications. This feature minimizes non-specific binding, making it ideal for antifouling coatings or biosensors.
Handling and Storage
To maintain quality, store t-Boc-N-Amido-PEG11-Azide at −20°C in a dry, inert atmosphere. Moreover, protect it from light and moisture. Avoid exposing it to strong acidic or basic conditions, as these can degrade its functional groups.
Overall, this product delivers a powerful combination of chemical functionality and practical usability. With its dual reactive groups and a PEG11 spacer that ensures solubility and flexibility, this compound significantly excels in click chemistry, drug delivery, and material science. Whether for bioconjugation or advanced surface modifications, it provides a reliable and efficient solution.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
