t-Boc-N-Amido-PEG11-amine
This product is a high-purity heterobifunctional PEG linker featuring a terminal amine group and a tert-butoxycarbonyl (t-Boc)–protected amine at opposite ends, connected by a PEG11 spacer. The free amine enables immediate conjugation to activated esters, isocyanates, or other electrophiles, while the t-Boc group can be selectively removed under mild acidic conditions (e.g., TFA) to yield a second primary amine for sequential or orthogonal functionalization. The PEG11 chain imparts especially excellent hydrophilicity, flexibility, and aqueous solubility, minimizing steric hindrance in bioconjugation or surface modification applications.
Key Features
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Heterobifunctional PEG with free amine and t-Boc–protected amine groups
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Orthogonal reactivity via selective t-Boc deprotection
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PEG11 spacer provides hydrophilicity, flexibility, and extended reach
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High chemical purity for reliable performance
Applications
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Sequential protein, peptide, and antibody conjugation
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Prodrug and polymer–drug conjugate development
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Biomolecule and surface modification
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Nanoparticle functionalization with controlled spacing
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Allow to reach room temperature before opening
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Avoid repeated freeze–thaw cycles
This product combines a free amine with an acid-labile t-Boc–protected amine, linked by a PEG11 chain specifically for solubility, flexibility, and orthogonal conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
