t-Boc-N-Amido-PEG1-acid
This product is a compact PEG1 linker with a Boc-protected amide and a terminal carboxylic acid. The short PEG1 spacer provides limited hydrophilicity and spacing, while the Boc group offers acid-labile protection for controlled, orthogonal conjugation workflows.
Key Features and Benefits:
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Boc-Protected Amide: Acid-labile protection for selective, stepwise synthesis.
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Carboxylic Acid Group: Couples efficiently with amines to form stable amide bonds.
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PEG1 Spacer: Compact hydrophilic chain minimizes steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Reactivity: Enables multifunctional and controlled synthesis strategies.
Applications:
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Bioconjugation: Compact PEG linker for precise protein, peptide, and biomolecule conjugation.
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Drug Delivery: Improves solubility and stability in therapeutic conjugates.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, or polymers.
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Synthetic Chemistry: Useful intermediate in orthogonal scaffold and linker design.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain Boc and acid stability.
This product combines compact PEG spacing with dual functionality, making it an especially versatile tool for orthogonal synthesis, bioconjugation, and advanced material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
