t-Boc-Aminooxy-PEG3-thiol is a crosslinker containing a t-Boc-aminooxy group and a thiol group. The protected aminooxy can be deprotected under mild acidic conditions. The aminooxy has been used to conjugate with carbonyl bearing (ketone and aldehyde) biomolecules to form oxime for reversible linkage spacer.Oxime ligation is one of the hot topics in the field of bioconjugation of molecules due to its chemoselectivity and hydrolytic stability. The PEG spacer increases the aqueous solubility of the resulting compound. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.