SPDP-PEG8-NHS ester
This product is a heterobifunctional crosslinker combining an SPDP (succinimidyl 3-(2-pyridyldithio)propionate) moiety with an NHS ester, specifically connected by a PEG8 spacer. This design allows amine-reactive conjugation and disulfide-exchange functionality, while the PEG8 chain improves solubility, spacing, and flexibility for bioconjugation, drug delivery, and probe design.
Key Features and Benefits:
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SPDP Group: Enables reversible disulfide linkage with thiols.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG8 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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Dual Functionality: Supports orthogonal thiol and amine conjugation.
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High Purity: Provides reproducibility for sensitive workflows.
Applications:
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Bioconjugation: Links thiol- and amine-containing biomolecules.
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Drug Delivery: Provides cleavable PEGylated scaffolds for targeted therapeutics.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Synthetic Chemistry: Useful in modular linker design with disulfide control.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect from NHS ester hydrolysis.
This product combines reversible disulfide chemistry with amine reactivity in a PEG8 scaffold, specifically offering solubility and versatility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
