SPDP-PEG4-NHS ester
This product is a cleavable crosslinker with an NHS ester for amine coupling and a pyridyldithiol group for thiol reactivity. The PEG4 spacer enhances solubility, flexibility, and accessibility, making it specifically used in reversible protein crosslinking and bioconjugation.
Key Features and Benefits:
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NHS Ester: Couples rapidly with primary amines to form stable amide bonds.
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Pyridyldithiol Group: Reacts with thiols and introduces a cleavable disulfide bond.
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PEG4 Spacer: Improves hydrophilicity, steric spacing, and flexibility.
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Reversible Design: Enables controlled conjugation and release under reducing conditions.
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High Purity: Ensures reproducibility in protein and probe conjugation.
Applications:
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Protein Crosslinking: Links lysine and cysteine residues with cleavable disulfide bonds.
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Bioconjugation: Combines amine and thiol reactivity for multifunctional assembly.
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Drug Delivery: Supports reversible conjugation for controlled release systems.
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Probe Development: Builds disulfide-cleavable imaging or affinity probes.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to moisture.
This product provides reversible thiol–amine conjugation with enhanced solubility, making it an especially versatile tool for protein crosslinking, bioconjugation, and controlled drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
