SPDP-PEG11-SPDP
This product is a symmetric, cleavable crosslinker featuring two SPDP (succinimidyl 3-(2-pyridyldithio)propionate) groups connected by a PEG11 spacer. This design enables dual thiol-reactive conjugations with disulfide-cleavable functionality, while the PEG11 chain enhances solubility, flexibility, and steric spacing for bioconjugation, ADC development, and probe design.
Key Features and Benefits:
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Dual SPDP Groups: Provide thiol reactivity and cleavable disulfide bonds.
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PEG11 Spacer: Enhances hydrophilicity, solubility, and spacing.
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Cleavable Linkage: Enables controlled release via disulfide reduction.
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Symmetric Design: Facilitates balanced crosslinking strategies.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
Applications:
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Bioconjugation: Links thiol-containing biomolecules with cleavable control.
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ADC Development: Builds disulfide-cleavable antibody–drug conjugates.
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Probe Development: Enables cleavable probes for imaging and diagnostics.
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Drug Delivery: Supports redox-sensitive linker strategies for targeted release.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature hydrolysis or reduction.
This product combines disulfide-cleavable reactivity with PEG-enhanced solubility, making it an especially versatile symmetric linker for bioconjugation, ADC design, and redox-sensitive delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.