SPDP-C6-Gly-Leu-NHS ester
This product is a heterobifunctional crosslinker combining an NHS ester, a reducible disulfide spacer (SPDP), and a Gly-Leu peptide sequence connected by a C6 linker. It specifically enables selective amine conjugation and cleavable disulfide-based release in bioconjugation workflows.
Key Features and Benefits
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NHS Ester: Reacts efficiently with primary amines to form stable amide bonds.
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SPDP Moiety: Provides a reducible disulfide linkage for controlled release.
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C6 Spacer: Increases solubility and flexibility for biomolecule coupling.
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Gly-Leu Peptide: Adds a biodegradable peptide motif for targeted applications.
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High Purity: Supports reproducible results in sensitive conjugation studies.
Applications
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Bioconjugation: Couples proteins, peptides, or small molecules via amine chemistry.
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Controlled Release: Enables disulfide cleavage under reducing conditions.
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Probe Development: Builds multifunctional probes with peptide and disulfide handles.
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Drug Delivery: Provides cleavable linkers for targeted release of therapeutics.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product combines amine-reactive NHS chemistry, a reducible disulfide spacer, and a biodegradable peptide, specifically providing a multifunctional linker for advanced drug delivery and bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
