Propargyl-PEG3-thiol
This product is a heterobifunctional PEG3 linker with a terminal alkyne for click chemistry and a thiol group for selective conjugation. The PEG3 spacer provides hydrophilicity, flexibility, and compact spacing, making it especially useful for bioconjugation, drug delivery, and surface engineering.
Key Features and Benefits:
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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Thiol Group: Reacts selectively with maleimides, haloacetyls, and disulfides.
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PEG3 Spacer: Provides compact hydrophilicity and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Combines click-ready alkyne and thiol chemistry for orthogonal use.
Applications:
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Click Chemistry: Bioorthogonal azide–alkyne ligation for labeling and probe design.
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Bioconjugation: Facilitates thiol–maleimide coupling and multifunctional modification.
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Drug Delivery: PEGylated linker enhances solubility, stability, and controlled release.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve thiol and alkyne integrity.
This product provides dual click and thiol reactivity in a compact PEG framework, making it an especially versatile building block for advanced conjugation, drug delivery, and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
