Propargyl-PEG2-CH2CO2-NHS Ester (CAS: 2244145-13-7)
Propargyl-PEG2-CH2CO2-NHS Ester acts as a versatile PEG-based linker for bioconjugation and chemical synthesis. Its propargyl (alkyne) group supports copper-catalyzed azide-alkyne cycloaddition (CuAAC), commonly referred to as “click chemistry,” enabling efficient conjugation with azide-containing molecules. Meanwhile, its NHS ester forms stable amide bonds with primary amines, allowing seamless attachment of biomolecules. Additionally, the PEG2 spacer improves water solubility and molecular flexibility, reducing steric hindrance during complex reactions.
Key Features:
- Reactive Groups:
- Propargyl (Alkyne): Supports CuAAC reactions, facilitating bioconjugation through azide-alkyne coupling.
- NHS Ester: Binds to primary amines, creating stable amide bonds for biomolecule attachment.
- PEG2 Spacer:
- Enhances solubility in aqueous environments.
- Provides flexibility while minimizing steric interference.
Applications:
- Bioconjugation:
- Attaches biomolecules such as peptides, proteins, and antibodies through click chemistry and amine coupling.
- PROTAC Synthesis:
- Functions as a linker for proteolysis-targeting chimeras (PROTACs), enabling protein degradation through the ubiquitin-proteasome pathway.
Handling and Storage:
- Molecular Formula: C₁₁H₁₃NO₆
- Molecular Weight: 255.22 g/mol
- Storage Recommendations:
- Store in a cool, dry place, protected from light and moisture, to maintain stability.
Overall, Propargyl-PEG2-CH2CO2-NHS Ester supports advanced molecular research with its dual reactivity and solubility-enhancing PEG2 spacer. Its compatibility with click chemistry and amine coupling makes it significantly essential for bioconjugation, targeted drug delivery, and cutting-edge therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
