Propargyl-PEG12-thiol
This product is a high-purity PEG linker with a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry and a thiol for selective coupling with maleimides, gold surfaces, or other thiol-reactive species. The PEG12 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Propargyl Group – Supports CuAAC click chemistry with azide-containing molecules for stable triazole linkage formation.
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Thiol Group – Reacts selectively with maleimides, haloacetyls, disulfides, and gold surfaces.
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PEG12 Spacer – Improves solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential and site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent and reproducible performance.
Applications
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Dual-functional linker for orthogonal bioconjugation
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Protein, peptide, and small molecule modification
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Surface immobilization on gold substrates and nanoparticles
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Antibody–drug conjugate (ADC) development
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Multifunctional probe and biosensor synthesis
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; protect thiol from oxidation by working under inert atmosphere or adding stabilizers
This product combines a propargyl group for CuAAC click chemistry with a thiol for thiol–maleimide or gold surface conjugation, separated by a PEG12 spacer for solubility and flexibility, enabling especially efficient orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
