Propargyl-PEG1-SS-PEG1-PFP Ester (CAS: 1817735-30-0) is a cleavable PEG linker used in bioconjugation and targeted drug delivery. It features a propargyl group for click chemistry (CuAAC), a PFP ester for amine coupling, and a disulfide bond for controlled cleavage under reductive conditions.
Key Features:
- Functional Groups: Propargyl (alkyne) for click chemistry, PFP ester for amine-reactive conjugation, and a cleavable disulfide bond.
- Molecular Formula: C₁₆H₁₅F₅O₄S₂
- Molecular Weight: 430.41 g/mol
- Purity: Typically ≥95%
Applications:
- Antibody-Drug Conjugates (ADCs): Works as a cleavable linker for precise drug attachment in cancer therapy.
- Bioconjugation: Enables the efficient conjugation of biomolecules using amine coupling and click chemistry.
- Protein Labeling: Facilitates protein tagging with various probes.
- Click Chemistry Reactions: Supports copper-catalyzed azide-alkyne cycloaddition (CuAAC), forming stable triazole linkages.
- Targeted Drug Delivery: Allows for controlled drug release due to its disulfide bond’s cleavability.
This linker is ideal for research and development in biomedicine, including targeted therapeutics and molecular diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
