PLLA-PEG-Amine (PLLA-PEG-NH2), MW x 1K, n 3K combines a 1K PLLA segment, 3K PEG segment, and terminal primary amine (–NH₂) in a biodegradable block copolymer and specifically supports bioconjugation, ligand attachment, nanoparticle development, and functional biomaterial research.
Key Features and Benefits
- Block Copolymer Structure: Combines hydrophobic poly(L-lactide) (PLLA) with hydrophilic polyethylene glycol (PEG) for amphiphilic polymer design.
- PLLA MW 1K: The 1K PLLA segment provides a biodegradable hydrophobic component for polymer assembly and material research.
- PEG MW 3K: The 3K PEG segment specifically provides a hydrophilic component and flexible polymer spacer for conjugation and formulation studies.
- Primary Amine Functionality: Terminal amine (–NH₂) provides a versatile reactive site specifically for conjugation and further polymer modification.
- Amine-Reactive Coupling: Compatible with NHS esters, activated carboxylic acids, and other amine-reactive functional groups.
- Stable Amide Formation: Coupling with activated carboxyl groups can produce stable covalent amide linkages.
- Amphiphilic Character: The PLLA and PEG blocks specifically provide hydrophobic and hydrophilic regions for self-assembly and formulation research.
- Biodegradable Polymer Platform: Combines biodegradable PLLA with hydrophilic PEG for functional polymer and biomaterial development.
Applications
- Bioconjugation: Attachment of peptides, proteins, ligands, dyes, and other compatible molecules through amine-reactive chemistry.
- Ligand Conjugation: Preparation of functional polymer conjugates for targeting and molecular recognition research.
- Nanoparticle Research: Development and functionalization of polymeric nanoparticles and related nanoscale systems.
- Polymeric Micelles: Amphiphilic PLLA and PEG blocks support research into self-assembled polymeric structures.
- Drug Delivery Research: Development and evaluation of biodegradable polymer-based delivery systems.
- Surface Modification: Primary amine functionality supports covalent attachment to appropriately activated surfaces and materials.
- Polymer Functionalization: Useful as a reactive polymer intermediate for introducing additional functional groups or molecular components.
- Biomaterial Research: Development of biodegradable, PEG-containing functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLLA-PEG-Amine (PLLA-PEG-NH2), MW x 1K, n 3K combines biodegradable PLLA, hydrophilic PEG, and reactive primary amine functionality, while its block composition supports conjugation, self-assembly, nanoparticle, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.