PEI-PEG-PEI, MW n 10K, m 5K is a cationic amphiphilic triblock copolymer composed of polyethyleneimine (PEI) and polyethylene glycol (PEG). It combines amine-rich PEI blocks with a hydrophilic PEG segment specifically for biomolecular complexation, polymer functionalization, and biomaterial research.
Key Features and Benefits
- Triblock Copolymer Structure: Features a PEI-PEG-PEI architecture with cationic PEI blocks and a central hydrophilic PEG segment.
- PEI MW 10K: Provides higher molecular weight polyethyleneimine blocks with abundant protonatable amine groups for electrostatic interactions.
- PEG MW 5K: Provides a hydrophilic polyethylene glycol segment that balances the cationic PEI blocks.
- Cationic Character: PEI provides positive charge under suitable pH conditions for interactions with negatively charged molecules and materials.
- Amine-Rich Structure: Multiple PEI amine groups specifically provide sites for electrostatic interactions and further chemical functionalization.
- PEI-Rich Composition: The 10K PEI blocks and 5K PEG segment give the copolymer a stronger cationic character than PEG-rich variants.
- Hydrophilic PEG Segment: PEG contributes hydrophilicity and helps tune the physicochemical properties of the triblock copolymer.
- Functionalization Platform: PEI amine groups provide multiple sites specifically for conjugation with compatible amine-reactive molecules.
Applications
- Biomolecular Complexation: Cationic PEI blocks support electrostatic interactions with compatible negatively charged biomolecules and materials.
- Nucleic Acid Complexation: Supports research involving electrostatic complexation with compatible DNA, RNA, and other polyanionic molecules.
- Polymer Functionalization: PEI amine groups provide multiple sites for introducing additional functionality.
- Nanoparticle Formulation: Supports development of cationic polymeric nanoparticles and related nanoscale systems.
- Polymer Complexation: Supports formation and study of complexes with compatible anionic polymers and materials.
- Drug Delivery: Supports development of functional cationic polymer systems for delivery research.
- Surface Modification: Amine-rich PEI blocks support development of functional coatings and modified surfaces.
- Biomaterial Research: Supports development of cationic polymer systems, complexes, nanoparticles, surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PEI-PEG-PEI, MW n 10K, m 5K combines amine-rich cationic PEI blocks with a hydrophilic 5K PEG segment and specifically supports biomolecular complexation, polymer functionalization, nanoparticle formulation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.